中级职称
首页 >> 师资队伍 >> 中级职称 >> 雷蓓蕾
 

雷蓓蕾

作者:wangyoucai    来源:     发布日期:2015-09-24     浏览次数:

     

  

  

个人简介:

雷蓓蕾,女,1984年生。2006年6月在兰州大学化学化工学院取得理学学士学位;2011年6月在兰州大学化学化工学院取得理学博士学位;2009年9月至2011年4月在美国肯塔基大学(University of Kentucky)药学院学习交流。2011年7月至今在西北农林科技大学生命科学学院工作。

主讲课程:

主要承担本科生《生物信息学》、《生物信息学实习》等课程的教学工作。

研究方向:

计算机辅助药物设计;分子模拟方法和机器学习算法在化学、生命科学等领域的应用。

学术及科研成果:

主持的科研项目

国家自然科学基金:基于靶标BRI1的新型油菜素内酯受体激动剂的合理设计,2014.1 – 2016.12

博士科研启动基金:丙型肝炎病毒耐药性机理的分子模拟研究,2011.10 – 2013.12。

发表论文

Lei, B. L.*, Li, J. Z., and Yao, X. J., A Novel Strategy of Structural Similarity Based Consensus Modeling. Molecular Informatics, 2013. 32(7): p. 599-608.
Lei, B. L., Adel, H. and Zhan, C.-G.*, Structural features and binding free energies for non-covalent inhibitors interacting with immunoproteasome by molecular modeling and dynamics simulations. Theoretical Chemistry Accounts, 2012. 131(4): p. 1203-1213.
Lei, B. L., Hameed, Mdma, Hamza, A., Wehenkel, M., Muzyka, J. L., Yao, X. J., Kim, K. B., and Zhan, C. G.*, Molecular Basis of the Selectivity of the Immunoproteasome Catalytic Subunit LMP2-Specific Inhibitor Revealed by Molecular Modeling and Dynamics Simulations. Journal of Physical Chemistry B, 2010. 114(38): p. 12333-12339.
Lei, B. L., Ma, Y. M., Li, J. Z., Liu, H. X., Yao, X. J.*, and Gramatica, P., Prediction of the adsorption capability onto activated carbon of a large data set of chemicals by local lazy regression method. Atmospheric Environment, 2010. 44(25): p. 2954-2960.
Lei, B. L., Li, J. Z., Lu, J., Du, J., Liu, H. X., and Yao, X. J.*, Rational Prediction of the Herbicidal Activities of Novel Protoporphyrinogen Oxidase Inhibitors by Quantitative Structure-Activity Relationship Model Based on Docking-Guided Active Conformation. Journal of Agricultural and Food Chemistry, 2009. 57(20): p. 9593-9598.
Lei, B. L., Li, S. Y., Xi, L. L., Li, J. Z., Liu, H. X., and Yao, X. J.*, Novel approaches for retention time prediction of oligonucleotides in ion-pair reversed-phase high-performance liquid chromatography. Journal of Chromatography A, 2009. 1216(20): p. 4434-4439.
Lei, B. L., Xi, L. L., Li, J. Z., Liu, H. X., and Yao, X. J.*, Global, local and novel consensus quantitative structure-activity relationship studies of 4-(Phenylaminomethylene) isoquinoline-1, 3 (2H, 4H)-diones as potent inhibitors of the cyclin-dependent kinase 4. Analytica Chimica Acta, 2009. 644(1-2): p. 17-24.
Lei, B. L., Du, J., Li, S. Y., Liu, H. X., Ren, Y. Y., and Yao, X. J.*, Comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) of thiazolone derivatives as hepatitis C virus NS5B polymerase allosteric inhibitors. Journal of Computer-Aided Molecular Design, 2008. 22(10): p. 711-725.
Lei, B. L., Li, J. Z., Liu, H. X., and Yao, X. J.*, Accurate prediction of aquatic toxicity of aromatic compounds based on Genetic Algorithm and Least Squares Support Vector Machines. Qsar & Combinatorial Science, 2008. 27(7): p. 850-865.
Wei, D. H., Lei, B. L., Tang M. S., and Zhan C.-G.*, Fundamental Reaction Pathway and Free Energy Profile for Inhibition of Proteasome by Epoxomicin, Journal of the American Chemical Society, 2012. 134(25): p. 10436-10450.
Qin, J., Lei, B. L., Xi, L. L., Liu, H. X., and Yao, X. J.*, Molecular modeling studies of Rho kinase inhibitors using molecular docking and 3D-QSAR analysis. European Journal of Medicinal Chemistry, 2010. 45(7): p. 2768-2776.
Du, J., Lei, B. L., Qin, J., Liu, H. X., and Yao, X. J.*, Molecular modeling studies of vascular endothelial growth factor receptor tyrosine kinase inhibitors using QSAR and docking. Journal of Molecular Graphics & Modelling, 2009. 27(5): p. 642-654.
Li, J. Z., Lei, B. L., Liu, H. X., Li, S. Y., Yao, X. J.*, Liu, M. C., and Gramatica, P., QSAR Study of Malonyl-CoA Decarboxylase Inhibitors Using GA-MLR and a New Strategy of Consensus Modeling. Journal of Computational Chemistry, 2008. 29(16): p. 2636-2647.
Chang, J., Lei, B. L., Li, J. Z., Li, S. Y., Shen, Y. L., and Yao, X. J.*, Accurate and Validated Quantitative Structure - Activity Relationship Model of Caspase-mediated Apoptosis-inducing Activity of Phenolic Compounds Using Density Functional Theory Calculation and Genetic Algorithm - Multiple Linear Regression. Qsar & Combinatorial Science, 2008. 27(11-12): p. 1318-1325.
Du, J., Xi, L. L., Lei, B. L., Lu, J., Li, J. Z., Liu, H. X., and Yao, X. J.*, Structure-Based Quantitative Structure-Activity Relationship Studies of Checkpoint Kinase 1 Inhibitors. Journal of Computational Chemistry, 2010. 31(15): p. 2783-2793.
Li, J. Z., Li, S. Y., Lei, B. L., Liu, H. X., Yao, X. J.*, Liu, M. C., and Gramatica, P., A New Strategy to Improve the Predictive Ability of the Local Lazy Regression and Its Application to the QSAR Study of Melanin-Concentrating Hormone Receptor 1 Antagonists. Journal of Computational Chemistry, 2010. 31(5): p. 973-985.

联系方式:

通讯地址:陕西杨凌,西北农林科技大学生命科学学院

邮政编码:712100

E-mail: leibl@nwsuaf.edu.cn

版权所有:  西北农林科技大学生命学院    地址:陕西杨凌农业高新技术产业示范区西农路22号  邮编:712100

主管领导:徐海            技术支持:艾特网络