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王永华

作者:wangyoucai    来源:     发布日期:2015-09-22     浏览次数:

     

1、基本情况


王永华,男,1973年8月生,安徽省合肥市人,教授,博士生导师。1997年本科毕业于大连理工大学,2006年硕博连读毕业于中科院大连化学物理研究所,获工学博士学位,同年至大连海洋大学任教,聘为副教授。2009年在都灵理工大学做访问教授。2010年调至西北农林科技大学工作至今,任教授。


2、研究方向


系统药理学理论和方法


开展基于系统药理学的中药作用机制、复方优化和新药开发


心脑血管病系统生物学和系统医学研究


3、社会兼职


学术刊物MicroRNA 杂志Associate editor.


4 、获奖


第九届陕西青年科技奖


2012年陕西省科学技术进步奖二等奖,第一名


2012年度杨凌示范区科学技术奖一等奖,第一名


2006年辽宁省自然科学学术成果二等奖,第一名


5 、开设课程和研究生培养


先后承担本科生生物信息学、过程模拟和优化等课程教学,为博、硕士研究生讲授计算生物学进展、计算系统生物学、药物学等课程。目前已培养硕士研究生15名;在读硕士研究生12名,博士研究生5名。


6 、主持项目


细胞内随机时-空模拟理论、计算方法及在计算系统生物学中的应用,国家自然科学基金,2009-2011。编号:10801025


肿瘤发生的数学模拟研究。国家自然科学基金,编号:10911130216/A011403


中药治疗自身免疫性疾病复方作用原理计算机预测与验证研究, 中国中医科学院专项基金,2011-2012。


甲型H1N1流感、手足口病中药筛选和适宜技术产品的研发。中医药行业科研专项子课题,2011-2012。


细胞分子网络混合尺度动力学理论及其在系统生物学上的应用。国家自然科学基金,2012-2016,编号:31170796。


醒脑静脑部疾病的网络药理学研究,企业横向课题,2012-2013。


基于生物信息学技术的克服P450介导的昆虫抗药性新型农药优化和开发。农药国家重点实验室开放课题。2012-2013。


西北农林科技大学科研启动基金。2011-2013。


7 、代表性文章


先后在Briefings in Bioinformatics, Nucleic Acids Research, PLoS Computational Biology, PLoS ONE, Current Medicinal Chemistry和Journal of Ethnopharmacology等刊物上发表SCI 论文70余篇。目前申请新药专利9项。


主要文章 (* 通讯作者)


1


Huang C, Zheng C, Li Y, Wang Y*, Lu A, Yang L. Systems Pharmacology in Drug Discovery and Therapeutic Insight for Herbal Medicines, Briefings in Bioinformatics, 2013, in press, (IF:5.2)


2


Zhang L, Liu T, Wang X, Wang J, Li G, Li Y, Yang L, Wang Y*. Insight into the binding mode and the structural features of the pyrimidine derivatives as human A2A adenosine receptor antagonists, BioSystems,2013 May 8. pii: S0303-2647(13)00090-7.


3


Liu H, Wang J, Zhou W, Wang Y*, Yang L. Systems Approaches and Polypharmacology for Drug Discovery from Herbal Medicines: An Example Using Licorice, Journal of Ethnopharmacology, 2013 Apr 19;146(3):773-93. (IF:3.0)


4


Wei Zhou, Chao Huang, Yan Li, Jinyou Duan, Yonghua Wang*, Ling Yang. A systematic identification of multiple toxin-target interactions based on chemical, genomic and toxicological data Toxicology, 2013,Feb 8;304:173-84. (IF:4.01)


5


Wang X, Xu X, Li Y, Li X, Tao W, Li B, Wang Y*, Yang L.Systems pharmacology uncovers Janus functions of botanical drugs: activation of host defense system and inhibition of influenza virus replication. Integrative Biology. 2013 Jan 28;5(2):351-71. (IF:4.5) [GreenMedInfo 报道 ]


6


Bohui Li, Xue Xu, Xia Wang, Hua Yu, Xiuxiu Li, Weiyang Tao, Yonghua Wang *, Ling Yang. A systems biology approach to understanding the mechanisms of action of Chinese herbs for treatment of cardiovascular disease. Int. J. Mol. Sci. 2012 Oct 19;13(10):13501-20. (IF:2.5)[ Pharmaceutical Intelligence 报道 ]


7


Xia Wang, Xue Xu, Weiyang Tao, Yan Li, Yonghua Wang* and Ling Yang. A systems biology approach to uncover pharmacological synergy in herbal medicines with applications to cardiovascular disease. Evidence-Based Complementary and Alternative Medicine. 2012:519031. IF=4.78


8


Weiyang Tao, Xue Xu, Yonghua Wang*. Network pharmacology-based prediction of the active ingredients and potential targets of Chinese herbal Radix Curcumae formula for application to cardiovascular disease. Journal of Ethnopharmacology 145 (2013), pp. 1-10 (IF:3.3)


9


Xiuxiu Li, Xue Xu, Jinan Wang, Hua Yu, Xia Wang, Hongjun Yang, Haiyu Xu, Shihuan Tang, Yan Li, Ling Yang, Luqi Huang, Yonghua Wang*, Shengli Yang, Ling Yang. A System-Level Investigation into the Mechanisms of Chinese Traditional Medicine: Compound Danshen Formula for Cardiovascular Disease Treatment. PLoS ONE, 2012;7(9):e43918.(IF=4.0)


10


Hua Yu, Yao Yao, Xue Xu, Jinan Wang, Wei Wang, Yonghua Wang*. A Systematic Prediction of Multiple Drug-Target Interactions from Chemical, Genomic and Pharmacological Data. PLoS ONE, 2012, 7(5):e37608 (IF: 4.3)。


11


Qinfan Li, Yupeng Fang, Xiuxiu Li, Hong Zhang, Mengmeng Liu, Huibin Yang, Zhuo Kang, Yan Li, Yonghua Wang *. Mechanism of the plant cytochrome P450 for herbicide resistance: a modelling study. Journal of Enzyme Inhibition and Medicinal Chemistry, 2012; Early Online: 1-10. (IF:1.5)


12


Xue Xu, Xia Wang,Yan Li, Yonghua Wang*, Ling Yang A large-scale genome-wide association study for nanoparticle C60 uncovers mechanisms of nanotoxicity disrupting the native conformations of DNA/RNA. Nucleic Acids Research, 2012, 1-11. doi:10.1093/nar/gks517, (IF:8.01)


13


Fangfang Wang, Zhi Ma, Yan Li, Jinan Wang and Yonghua Wang*, Structural requirements of pyrimidine, thienopyridine and ureido thiophene carboxamide-based inhibitors of the checkpoint kinase 1: QSAR, docking, molecular dynamics analysis, Journal of Molecular Modeling Volume 18, Number 7 (2012), 3227-3242.


14


Xue Xu, Wuxia Zhang, Chao Huang, Yan Li, Hua Yu, Yonghua Wang*, Jinyou Duan*, Yang Ling. A Novel Chemometric Method for the Prediction of Human Oral Bioavailability. Int. J. Mol. Sci. 2012, 13(6), 6964-6982


15


Hong Zhang, Yao Yao, Huibin Yang, Xia Wang, Zhuo Kang, Yan Li, Guohui Li, Yonghua Wang*. Molecular Dynamics and Free Energy Studies on the Carboxypeptidases Complexed with Peptide/Small molecular Inhibitor: Mechanism for Drug Resistance. 2012, Insect Biochem Mol Biol., 2012, 42, 583-595 .(IF: 4.1)


16


Jianling Liu, Mengmeng Liu, Yao Yao Jinan Wang Yan Li , Guohui Li,Yonghua Wang*, Identi?cation of novel potential β-N-acetyl-D-hexosaminidase inhibitors by virtual screening, molecular dynamics simulation and MM-PBSA calculations. 2012, Int. J. Mol. Sci. 2012, 13. 4545-4561 (IF: 2.3)


17


Xia Wang, Xue Xu, Yonghua Wang*, Ling Yang. pH-dependent Channel Gating in Connexin26 Hemichannels Involves Conformational Changes in N-terminus. BBA - Biomembranes 1818 (2012), 1148-1157 (IF: 4.6)


18


Xue Xu, Ruibin Li, Xia Wang, Ming Ma, Yonghua Wang*, Hanfa Zou. Multidrug resistance protein P-glycoprotein does not recognize nanoparticle C60: experiment and modeling. Soft Matter, 2012, 8: 2915-2923 (IF: 4.6)


19


Xue Xu, Zhi Ma, Xia Wang, Zhengtao Xiao, Yan Li, Zhenghua Xue, Yonghua Wang*. Water's potential role: insights from studies of the p53 core domain. Journal of Structural Biology, 2012, 177: 358-366 (IF: 3.67)


20


Xue Xu, Xia Wang, Zhentao Xiao, Yan Li, Yonghua Wang*. Probing the structural and functional link between mutation- and pH-dependent hydration dynamics and amyloidosis of transthyretin. Soft Matter, 2012, 8: 324-336 (IF: 4.5)


21


Xia Wang, Xue Xu, Shanna Zhu, Zhengtao Xiao, Zhi Ma, Yan Li, Yonghua Wang*. Molecular dynamics simulation of conformational heterogeneity in Transportin 1. Proteins: Structure, Function, and Bioinformatics. 2012, 80: 382-397 (IF: 3.1)


22


Fangfang Wang, Yan Li, Zhi Ma, Xia Wang, Yonghua Wang*. Structural determinants of benzodiazepinedione/peptide-based p53-HDM(2) inhibitors using 3D-QSAR, docking and molecular dynamics. Journal of Molecular Modeling. 2012, 18(1): 295-306 (IF: 1.8)


23


Z Ma,HX Zhang, Yonghua Wang*. Local and global Effects of Mg2+ on Ago and miRNA-target interactions, J Mol Mode. 2012. (IF:1.8)


24


Qinfan Li, Xiangya Kong, Zhi Ma, Lihui Zhang, Fangfang Wang, Hong Zhang, Yonghua Wang*. Structural determinants of imidacloprid-based nicotinic acetylcholine receptor inhibitors using 3D-QSAR, docking and molecular dynamics. Journal of Molecular Modeling, 2011, DOI: 10.1007/s00894-011-1293-z (IF: 1.8)


25


Mengqi Zhang, Xiaole Zhang, Yan Li*, Wenjia Fan, Yonghua Wang, Ming Hao, Shuwei Zhang, Chunzhi Ai. Investigation on quantitative structure activity relationships and pharmacophore modeling of a series of mGluR2 antagonists. International Journal of Molecular Sciences, 2011, 12: 5999-6023 (IF: 2.3)


26


Ming Hao, Yan Li*, Yonghua Wang, Shuwei Zhang. A classification study of human β3-adrenergic receptor agonists using BCUT descriptors. Molecular Diversity, 2011, 15(4): 877-887 (IF: 3.7)


27


Jinan Wang, Fangfang Wang, Zhengtao Xiao, Guowen Sheng, Yan Li, Yonghua Wang*. Molecular simulation of a series of benzothiazole PI3Kα inhibitors: probing the relationship between structural features, anti-tumor potency and selectivity, Journal of Molecular Modeling, 2011, DOI: 10.1007/s00894-011-1299-6 (IF: 1.8)


28


Xia Wang, Xue Xu, Zhi Ma, Yingqiu Huo, Zhengtao Xiao, Yan Li, Yonghua Wang*. Dynamic mechanisms for pre-miRNA binding and export by Exportin-5. RNA, 2011, 17: 1511-1528 (IF: 6.09)


29


Ming Hao, Yan Li*, Yonghua Wang, Yulian Yan, Shuwei Zhang. Combined 3D-QSAR, molecular docking and molecular dynamics study on piperazinyl-glutamate-pyridines/pyrimidines as potent P2Y12 antagonists for inhibition of platelet aggregation. Journal of Chemical Information and Modeling, 2011, 51: 2560-2572 (IF: 3.8)


30


Wei Zhou, Yan Li, Xia Wang, Lianqi Wu, Yonghua Wang*. MiR-206-mediated dynamic mechanism of the mammalian circadian clock. BMC Systems Biology, 2011, 5:141 (IF: 3.6)


31


Ming Hao, Yan Li*, Yonghua Wang, Shuwei Zhang. A classification study of respiratory syncytial virus (RSV) inhibitors by variable selection with random forest. International Journal of Molecular Sciences, 2011, 12: 1259-1280 (IF: 2.3)


32


Zhengtao Xiao, Xia Wang , Xue Xu, Hong Zhang, Yan Li, Yonghua Wang*. Base- and Structure-Dependent DNA Dinucleotide-Carbon Nanotube Interactions: Molecular Dynamics Simulations and Thermodynamic Analysis. The Journal of Physical Chemistry C. 2011, 115(44): 21546-21558 (IF: 4.5)


33


Qinfan Li, Lihui Zhang, Zhi Ma, Xiangya Kong, Fangfang Wang, Hong Zhang, Yonghua Wang*. Probing Structural Features and Binding Mode of 3-Arylpyrimidin-2,4-diones within Housefly γ-Aminobutyric Acid (GABA) Receptor. International Journal of Molecular Sciences, 2011, 12(9): 6293-6311 (IF: 2.4)


34


Ming Hao, Yan Li*, Yonghua Wang, Shuwei Zhang. Prediction of P2Y12 antagonists using a novel genetic algorithm-support vector machine coulpled approach. Analytica Chimica Acta, 2011, 690: 53-63 (IF: 4.3)


35


Fangfang Wang, Zhi Ma, Yonghua Wang*. Development of in silico models for pyrazoles and pyrimidine derivatives as cyclin-dependent kinase 2 inhibitors. Journal of Molecular Graphics and Modelling. 2011, 30: 67-81 (IF: 2.4)


36


Huixiao Zhang, Yan Li, Xia Wang, Yonghua Wang*. Probing the Structural Requirements of A-type Aurora Kinase Inhibitors Using 3D-QSAR and Molecular Docking Analysis. Journal of Molecular Modeling. 2011, DOI: 10.1007/s00894-011-1042-3 (IF:1.8)


37


Jianling Liu, Hong Zhang, Zheng Tao Xiao, Fangfang Wang, Xia Wang, Yonghua Wang*. Combined 3D-QSAR, Molecular Docking and Molecular Dynamics Study on Derivatives of Peptide Epoxyketone and Tyropeptin-boronic acid as Inhibitors against β5 subunit of human 20S Proteasome. International Journal of Molecular Sciences, 2011, 12(3): 1807-1835 (IF:2.2)


38


Huixiao Zhang, Yan Li*, Xia Wang, Zhengtao Xiao, YH Wang. Insight into the Structural Requirements of Benzothiadiazine Scaffold-Based Derivatives as Hepatitis C Virus NS5B Polymerase Inhibitors Using 3D-QSAR, Molecular Docking and Molecular Dynamics. Current Medicinal Chemistry, 2011, 18(26): 4019-4028 (IF:4.6)


39


Jianling Liu, Fangfang Wang, Zhi Ma, Xia Wang and Yonghua Wang*. Structural Determination of Three Different Series of Compounds as Hsp90 Inhibitors Using 3D-QSAR Modeling, Molecular Docking and Molecular Dynamics Methods. International Journal of Molecular Sciences, 2011, 12(2): 947-956 (IF:2.2)


40


Ming Hao, Yan Li*, Yonghua Wang, Shuwei Zhang. A Classification Study of Respiratory Syncytial Virus (RSV) Inhibitors by Variable Selection with Random Forest. International Journal of Molecular Sciences, 2011, 12(2): 1259-1280 (IF:2.2)


41


Xue Xu, Heng Wang, Jingxuan Fu, Yonghua Wang*. Influence of P-glycoprotein on Embryotoxicity of Antifouling Biocides to Sea Urchin (Strongylocentrotus intermedius)。 Ecotoxicology, 2011, 20(2): 419-28 (IF:3.6)


42


Xue Xu, Xia Wang, Zhegtao Xiao, Yan Li, Yonghua Wang*. Two TPX2-Dependent Switches Control the Activity of Aurora A. PLoS ONE, 2011, 6(2): e16757 (IF: 4.3)


43


Xue Xu, Wei Yang, Xia Wang, Yan Li, Yonghua Wang*, Chunzhi Ai. Dynamic Communication between Androgen and Coactivator: Mutually-Induced Conformational Perturbations in Androgen Receptor Ligand-Binding Domain. Proteins: Structure, Function, and Bioinformatics, 2011, 79: 1154-1171 (IF:3.0)


44


Heng Wang, Yonghua Wang*. Toxicity evaluation of single and mixed antifouling biocides using the Strongylocentrotus intermedius sea urchin embryo test. Environmental Toxicology & Chemistry Journal, 2011, 30: 692-703 (IF:2.8)


45


Xue Xu, Yan Li, Yuan Wang and Yonghua Wang*. Assessment of toxic interactions of heavy metals in multi-component mixtures using sea urchin embryo-larval bioassay, Toxicology in Vitro, 2011, 25: 294-300 (IF:2.2)


46


Xue Xu, Xia Wang, Yan Li, Yonghua Wang*, Acute Toxicity and Synergism of Binary Mixtures of Antifouling Biocides with Heavy Metals to Embryos of Sea Urchin Glyptocidaris Crenularis. Human & Experimental Toxicology, 2011, 30: 1009-1021 (IF:1.8)


47


Ming Hao, Yan Li*, Yonghua Wang, Shuwei Zhang. Prediction of PKCθ inhibitory activity using the random forest algorithm. International Journal of Molecular Sciences, 2010, 11: 3413-3433 (IF: 2.3)


48


Yonghua Wang*, Yan Li, Zhi Ma, Wei Yang, Chunzhi Ai. Mechanism of microRNA-target interaction: molecular dynamics simulations and thermodynamics analysis. PLOS Computational Biology, 2010,6(7): e1000866 (IF:5.8)


49


Zhizhong Wang, Yan Li, Chunzhi Ai, Yonghua Wang*. In Silico Prediction of Estrogen Receptor Subtype Binding Affinity and Selectivity Using Statistical Methods and Molecular Docking with 2-Arylnaphthalenes and 2-Arylquinolines. International Journal of Molecular Sciences, 2010, 11(9): 3434-3458 (IF:1.3)


50


Xia Wang, Wei Yang, Xue Xu, Huixiao Zhang, Yan Li, Yonghua Wang*. Studies of Benzothiadiazine Derivatives as Hepatitis C Virus NS5B Polymerase Inhibitors Using 3D-QSAR, Molecular Docking and Molecular Dynamics. Current Medicinal Chemistry, 2010, 17: 2788-2803 (IF:4.8)


51


Xia Wang, Yan Li, Xue Xu, Yonghua Wang*. Toward a system-level understanding of microRNA pathway via mathematical modeling. BioSystems, 2010, 100(1): 31-38. (IF:1.8)


52


Xue Xu, Wei Yang, Yan Li, Yonghua Wang*. Discovery of estrogen receptor modulators: a review of virtual screening and SAR Efforts. Expert Opinion on Drug Discovery, 2010, 5: 21-31 (IF:1.8)


53


Heng Wang, Honghui Huang, Jun Ding, Yonghua Wang*. Embryotoxicity and teratogenicity of the pesticide indoxacarb to sea urchin (Strongylocentrotus intermedius)。 Water Science and Technology, 2010, 61(11): 2733-9 (IF:1.0)


54


Shaopeng Wei, Zhiqin Ji, Huixiao Zhang, Jiwen Zhang, Yonghua Wang *, Wu WJ*. Isolation, biological evaluation and 3D QSAR studies on insecticidal/ narcotic sesquiterpene polyol esters. Journal of Molecular Modeling, 2010, 17: 681-693 (IF:2.0)


55


Chnzhi Ai, Yan Li, Yonghua Wang, Wei Li, Peipei Dong, Guangbo Ge, Ling Yang. Investigation of binding features: Effects on the interaction between P450 2A6 and inhibitors. Journal of computational chemistry, 2010, 31(9): 1822-1831


56


Gaoxue Wang, Yan Li, Xiaolin Liu, Yonghua Wang*. Understanding the Aquatic Toxicity of Pesticide:Structure-Activity Relationship and Molecular Descriptors to Distinguish the Ratings of Toxicity. QSAR & combinatorial Science, 2009, 28: 1418-1431 (IF:3.0)


57


Chunzhi Ai, Yan Li, Yonghua Wang, Yadong Chen, Ling Yang. Insight into the effects of chiral isomers quinidine and quinine on CYP2D6 inhibition. Bioorganic & medicinal chemistry letters, 2009, 19(3): 803-806


58


Yan Li, Yonghua Wang*, Jun Ding, Yuan Wang, Yaqing Chang, Shuwei Zhang. In Silico Prediction of Androgenic and Nonandrogenic Compounds Using Random Forest. QSAR & Combinatorial Science, 2009, 28(10): 396-405 (IF:3.0)


59


Xiuli Sun, Yan Li, Yonghua Wang*, Xianjie Liu, Jun Ding, Yaqing Chang, Hui Shen. Classification of bioaccumulative and non-bioaccumulative chemicals using statistical learning approaches. Molecular Diversity, 2008, 12:157-169 (IF:3.0)


60


Yonghua Wang*, Yan Li, Jun Ding, Yuan Wang, Yaqing Chang. Prediction of binding affinity for estrogen receptorα??modulators using statistical learning approaches. Molecular Diversity, 2008, 12: 93-102 (IF:3.0)


61


Yonghua Wang*, Yan Li, Jun Ding, Yaqing Chang. Estimation of bioconcentration factors using molecular electro-topological state and flexibility. SAR and QSAR in Environmental Research, 2008,19(3-4): 375-95 (IF:1.2)


62


ChunZhi Ai, Yonghua Wang, Yan Li, Yanhong Li, Ling Yang. A 3D-QSAR Study of Catechol-O-methyltransferase Inhibitors using CoMFA and CoMSIA. QSAR & Combinatorial Science, 2008, 27(10): 1183-1192 (IF:4.1)


63


Yonghua Wang, etc. Stochastic Simulations of the Cytochrome P450 Cycle. The journal of physical chemistry. B., 2007, 111 (16): 4251-4260 (IF:4.1)


64


Yonghua Wang, Yan Li, Bin Wang. An In Silico Method for Screening Nicotine Derivatives as Cytochrome P450 2A6 Selective Inhibitors Based on Kernel Partial Least Squares. International Journal of Molecular Sciences, 2007, 8: 166-179 (IF:1.3)


65


Yonghua Wang, Yan Li, Shengli Yang, etc. Investigations into the Analysis and Modeling of the Cytochrome P450 Cycle. The journal of physical chemistry. B., 2006, 110: 10139-43 (IF:4.1)


66


Yan LI, Yonghua Wang, Ling Yang, Shuwei Zhang, Changhou Liu. Structural Determinants of Flavones Interacting with the C-Terminal Nucleotide-Binding Domain as P-Glycoprotein Inhibitors. Internet Electronic Journal of Molecular Design, 2006, 5: 1-12 (IF:1.2)


67


Yan Li, Yonghua Wang, Ling Yang, Shuwei Zhang, etc. Impact of Molecular Hydrophobic Field on Passive Diffusion, P-Glycoprotein Active Efflux, and P-Glycoprotein Modulation of Steroids. Internet Electronic Journal of Molecular Design, 2006, 5: 60-78


68


Yanhong LI, Yonghua Wang, Ling Yang, etc. Distribution of the functional MDR1C3435T polymorphism in the Han population of China. Swiss Medical Weekly. 2006,136: 377-382. (IF:1.2)


69


Yanhong Li, Yonghua Wang, Yan LI, Ling Yang. MDR1 Gene Pharmacogenetics and the Clinical Relevance. Atca Genetica Sinica, 2006, 33: 93-104


70


Yanhong LI, Yonghua Wang, Yan Li, Ling Yang. Prediction of the Deleterious nsSNP in ABCB Transporters. FEBS Letters, 2006, 580: 6800-6806 (IF:3.4)


71


Yonghua Wang, Yan Li, Shengli Yang, etc. Classification of Substrates and Inhibitors of P-Glycoprotein Using Unsupervised Machine Learning Approach. Journal of Chemical Information and modeling, 2005, 45(3): 750-757 (IF:3.8)


72


Yonghua Wang, Yan Li, Shengli Yang, Ling Yang. An Insilico Approach for Screening Flavonoids as P-glycoprotein Inhibitors Based on Bayesian-regularized Neural Network. Journal of Computer-Aided Molecular Design, 2005, 19(3): 137-147 (IF:3.6)


73


Yonghua Wang, Yan Li, Yanhong Li, Shengli Yang, Ling Yang. Modeling Km Values Using Electrotopological State: Substrates for Cytochrome P450 3A4-Mediated Metabolism. Bioorganic & Medicinal Chemistry Letters, 2005, 15: 4076-4084 (IF:2.4)


74


Yan Li, Yonghua Wang, Ling Yang, Shuwei Zhang, Changhou Liu, Shengli Yang. Comparison of Steroid Substrates and Inhibitors of P-Glycoprotein by 3D-QSAR Analysis. Journal of Molecular Structure, 2005, 733: 110-118 (IF:1.2)


75


Yonghua Wang, Keli Han, Shengli Yang, Ling Yang. Structural Determinants of Steroids for Cytochrome P4503A4-Mediated Metabolism. Journal of Molecular Structure: THEOCHEM, 2004, 710: 215-221 (IF:1.2)


8 .联系方式


通讯地址:陕西杨凌西农路22号 西北农林科技大学生命科学学院


邮编:712100


Email: yh_wang@nwsuaf.edu.cn

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